Penatalaksanaan Sindrom Nefrotik

Oleh :

dr. Michael Sintong Halomoan

Penatalaksanaan sindrom nefrotik pada anak mencakup terapi imunosupresan seperti kortikosteroid. Pada dewasa, manfaat imunosupresan belum jelas. Tujuan penatalaksanaan adalah mengendalikan tanda dan gejala, serta mencegah dan mengobati komplikasi.

Pasien juga dapat diberikan diuretik untuk mengurangi retensi cairan. Bila ascites sangat berat, dapat dipertimbangkan untuk melakukan parasentesis abdomen. Antibiotik profilaksis juga mungkin diperlukan.[1-4]

Sindrom Nefrotik Anak

Referensi

1. Tapia C, Bashir K. Nephrotic Syndrome. StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. https://www.ncbi.nlm.nih.gov/books/NBK470444/
2. Sinnakirouchenan R. Nephrotic Syndrome. Medscape. 2021. https://emedicine.medscape.com/article/244631-overview#a1
3. O’Brien F. Overview of Nephrotic Syndrome. MSD Manual Professional Version. 2022. https://www.msdmanuals.com/professional/genitourinary-disorders/glomerular-disorders/overview-of-nephrotic-syndrome
4. Politano SA, Colbert GB, Hamiduzzaman N. Nephrotic syndrome. Primary Care: Clinics in Office Practice. 2020 Dec 1;47(4):597-613.
5. Wang CS, Greenbaum LA. Nephrotic syndrome. Pediatric Clinics. 2019 Feb 1;66(1):73-85.
6. Downie ML, Gallibois C, Parekh RS, Noone DG. Nephrotic syndrome in infants and children: pathophysiology and management. Paediatrics and International Child Health. 2017 Oct 2;37(4):248-58.
10. Downie ML, Gallibois C, Parekh RS, Noone DG. Nephrotic syndrome in infants and children: pathophysiology and management. Paediatrics and International Child Health. 2017 Oct 2;37(4):248-58.
11. Kodner C. Diagnosis and management of nephrotic syndrome in adults. American family physician. 2016 Mar 15;93(6):479-85.
12. Rovin BH, Adler SG, Barratt J, et al. KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney international. 2021 Oct 1;100(4):S1-276.
13. Sinha A, Bagga A. Clinical practice guidelines for nephrotic syndrome: consensus is emerging. Pediatric Nephrology. 2022 Jun 28:1-0.
14. Mühlig AK, Lee JY, Kemper MJ, et al. Levamisole in children with idiopathic nephrotic syndrome: clinical efficacy and pathophysiological aspects. Journal of Clinical Medicine. 2019 Jun 16;8(6):860.
15. Ehren R, Benz MR, Doetsch J, et al. Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre trial (INTENT study). BMJ open. 2018 Oct 1;8(10):e024882.
16. Basu B, Babu BG, Mahapatra TK. Long-term efficacy and safety of common steroid-sparing agents in idiopathic nephrotic children. Clinical and experimental nephrology. 2017 Feb;21(1):143-51.
17. Badawy Ali A, Abdel_Ghany AA, El Tellawy MM. Effectiveness and Safety of Cyclosporine A in Childhood Nephrotic Syndrome. GEGET. 2022 Jun 1;17(1):38-46.
18. Kari JA, Alhasan KA, Albanna AS, et al. Rituximab versus cyclophosphamide as first steroid-sparing agent in childhood frequently relapsing and steroid-dependent nephrotic syndrome. Pediatric Nephrology. 2020 Aug;35(8):1445-53.
28. The Royal Children’s Hospital Melbourne. Nephrotic Syndrome. 2019. https://www.rch.org.au/clinicalguide/guideline_index/Nephrotic_syndrome/

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