Indikasi Bayi Tabung

Oleh dr. Riawati Jahja

INDIKASI

Pada prinsipnya, indikasi tindakan bayi tabung (IVF) diutamakan pada pasangan suami-istri yang sudah lama tidak memiliki keturunan dan sudah menjalani tatalaksana fertilisasi lainnya, namun gagal.

Pada pria, indikasi bayi tabung adalah adanya faktor infertilitas pria seperti menurunnya jumlah dan atau motilitas sperma.

Pada wanita, indikasi bayi tabung adalah pada :

Wanita berusia ≥40 tahun yang infertil

Memiliki masalah ovarium, seperti gangguan ovulasi, insufisiensi ovarium, dan sel telur yang abnormal

Masalah pada tuba falopii, seperti kerusakan, obstruksi, atau sudah diangkat

Masalah uterus seperti fibroid uterus

Pasien wanita berusia ≥35 tahun dengan pasangan pria yang memiliki normalitas morfologi sperma <5%

Kelainan genetik

Gangguan infertilitas yang tidak dapat dijelaskan. [4,7,8]

Referensi

4. Lindsay, T. J., & Vitrikas, K. R. (2015). Evaluation and treatment of infertility. Am Fam Physician, 91(5), 308-314.
Tjon-Kon-Fat, R. I., Tajik, P., Zafarmand, M. H., Bensdorp, A. J., Bossuyt, P. M. M., Oosterhuis, G. J. E., et al. (2017). IVF or IUI as first-line treatment in unexplained subfertility: the conundrum of treatment selection markers. Hum Reprod, 32(5), 1028-1032. doi: 10.1093/humrep/dex037
8. Mayoclinic. In Vitro Fertilization. 2018. Available from : https://www.mayoclinic.org/tests-procedures/in-vitro-fertilization/about/pac-20384716

2. Elgindy, E. A., Abou-Setta, A. M., & Mostafa, M. I. (2011). Blastocyst-stage versus cleavage-stage embryo transfer in women with high oestradiol concentrations: randomized controlled trial. Reproductive BioMedicine Online, 23(6), 789-798. doi: 10.1016/j.rbmo.2011.08.011

3. Glujovsky, D., & Farquhar, C. (2016). Cleavage-stage or blastocyst transfer: what are the benefits and harms? Fertility and Sterility, 106(2), 244-250. doi: 10.1016/j.fertnstert.2016.06.029

4. Humm, K. C., Dodge, L. E., Wu, L. H., Penzias, A. S., Malizia, B. A., Sakkas, D., & Hacker, M. R. (2015). In vitro fertilization in women under 35: counseling should differ by age. J Assist Reprod Genet, 32(10), 1449-1457. doi: 10.1007/s10815-015-0570-7

5. Kallen, B., Finnstrom, O., Lindam, A., Nilsson, E., Nygren, K. G., & Olausson, P. O. (2010). Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome? Fertil Steril, 94(5), 1680-1683. doi: 10.1016/j.fertnstert.2009.12.027

6. Kamphuis, E. I., Bhattacharya, S., van der Veen, F., Mol, B. W. J., & Templeton, A. (2014). Are we overusing IVF? [10.1136/bmj.g252]. BMJ : British Medical Journal, 348.

7. Kaur, P., Swarankar, M. L., Maheshwari, M., & Acharya, V. (2014). A comparative study between cleavage stage embryo transfer at day 3 and blastocyst stage transfer at day 5 in in-vitro fertilization/intra-cytoplasmic sperm injection on clinical pregnancy rates. J Hum Reprod Sci, 7(3), 194-197. doi: 10.4103/0974-1208.142481

8. Kementerian Kesehatan Republik Indonesia. (2010). Peraturan MenKes RI tentang Peyelenggaraan Pelayanan Teknologi Reproduksi Berbantu, http://hukor.kemkes.go.id/uploads/produk_hukum/PMK%20No.%20039%20ttg%20Penyelenggaraan%20Pelayanan%20Reproduksi%20Berbantu.pdf

9.Lindsay, T. J., & Vitrikas, K. R. (2015). Evaluation and treatment of infertility. Am Fam Physician, 91(5), 308-314.

10. Mangalraj, A. M., Muthukumar, K., Aleyamma, T. K., Kamath, M. S., & George, K. (2009). Blastocyst stage transfer vs cleavage stage embryo transfer. Journal of Human Reproductive Sciences, 2(1), 23-26. doi: 10.4103/0974-1208.51339

11. Moeloek, F. A. (2014). Etika dan Hukum Teknik Reproduksi Buatan: Komisi Nasional Etik Penelitian Kesehatan, Litbang Depkes R.I.http://www.knepk.litbang.depkes.go.id/2014/wp-content/uploads/2014/08/human-cloning.pdf.

12. Parazzini, F., Cipriani, S., Bulfoni, G., Bulfoni, C., Frigerio, A., Somigliana, E., & Mosca, F. (2015). The risk of birth defects after assisted reproduction. Journal of Assisted Reproduction and Genetics, 32(3), 379-385. doi: 10.1007/s10815-014-0398-6

13. Pemerintah dan Parlemen Republik Indonesia. (2009). Undang Undang Republik Indonesia Nomor 36, Tahun 2009 tentang Kesehatan, Pasal 127: Upaya Kehamilan Diluar Cara Alamiah, http://sireka.pom.go.id/general/regulation

14. Pemerintah Republik Indonesia. (2014). Peraturan Pemerintah Republik Indonesia Nomor 61, Tahun 2014 tentang Kesehatan Reproduksi, http://www.bpkp.go.id/pencarian/result.bpkp

15. Pisarska, M. D. (2017). Fertility Status and Overall Health. Semin Reprod Med, 35(3), 203-204. doi: 10.1055/s-0037-1603728

16. The World Health Organization. (2017). Sexual and Reproductive Health: Infertility, http://www.who.int/reproductivehealth/topics/infertility/new/en/

17. Tjon-Kon-Fat, R. I., Tajik, P., Zafarmand, M. H., Bensdorp, A. J., Bossuyt, P. M. M., Oosterhuis, G. J. E., et al. (2017). IVF or IUI as first-line treatment in unexplained subfertility: the conundrum of treatment selection markers. Hum Reprod, 32(5), 1028-1032. doi: 10.1093/humrep/dex037

18. US Centers for Disease Control and Prevention. (Feb 2017). Assisted Reproductive Technology (ART), from https://www.cdc.gov/art/whatis.html

19. Wang, S.-S., & Sun, H.-X. (2014). Blastocyst Transfer Ameliorates Live Birth Rate Compared with Cleavage-Stage Embryos Transfer in Fresh In Vitro Fertilization or Intracytoplasmic Sperm Injection Cycles: Reviews and Meta-Analysis. Yonsei Medical Journal, 55(3), 815-825. doi: 10.3349/ymj.2014.55.3.815

20. Wiser, A., Shalom-Paz, E., Reinblatt, S. L., Son, W. Y., Das, M., Tulandi, T., & Holzer, H. (2012). Ovarian stimulation and intrauterine insemination in women aged 40 years or more [Abstract]. Reprod Biomed Online, 24(2), 170-173. doi: 10.1016/j.rbmo.2011.11.007

Alomedika | Khusus untuk Dokter

Indikasi Bayi Tabung

Referensi