Etiologi Inflammatory Bowel Disease

Oleh :

dr.Monica DS, MH

Etiologi Inflammatory Bowel Disease (IBD) adalah idiopatik atau belum diketahui secara pasti. Tetapi beberapa studi mengindikasikan bahwa IBD terjadi karena interaksi antara faktor genetik, gangguan mikrobioma, disregulasi sistem imun, dan faktor lingkungan.[2,3]

Faktor Genetik

Faktor genetik adalah salah satu faktor yang memiliki hubungan yang kuat dengan terjadinya IBD. Data dari Genome-Wide Association Studies menyebutkan bahwa terdapat lebih dari 230 single nucleotide polymorphisms (SNPs) yang terdeteksi berhubungan dengan IBD.

Referensi

1. Kucharzik T, Ellul P, Greuter T, Rahier JF, Verstockt B, Abreu C, et al. ECCO Guidelines on the Prevention, Diagnosis, and Management of Infections in Inflammatory Bowel Disease. Journal of Crohn’s and Colitis. 2021;879-913. DOI: https://doi.org/10.1093/ecco-jcc/jjac104.
2. Okobi OE, Udoete IO, Fasehun OO, Okobi T, Evbayekha EO, Ekabua JJ, Elukeme H, Ebong IL, Ajayi OO, Olateju IV, Taiwo A, Anaya IC, Omole JA, Nkongho MB, Ojinnaka U, Ajibowo AO, Ogbeifun OE, Ugbo OO, Okorare O, Akinsola Z, Olusoji RA, Amanze IO, Nwafor JN, Ukoha NA, Elimihele TA. A Review of Four Practice Guidelines of Inflammatory Bowel Disease. Cureus. 2021 Aug 3;13(8):e16859. doi: 10.7759/cureus.16859. PMID: 34513436; PMCID: PMC8413108.
3. Seyedian SS, Nokhostin F, Malamir MD. A Review of the Diagnosis, Prevention, and Treatment Methods of Inflammatory Bowel Disease. Journal of Medicine and Life. 2019;12(2):113-22.
5. McDowell C, Farooq U, Haseeb M. Inflammatory Bowel Disease. [Updated 2023 Apr 16]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK470312/
8. Nemati S, Teimourian S. An Overview of Inflammatory Bowel Disease: General Consideration and Genetic Screening Approach in Diagnosis of Early Onset Subsets. Middle East J Dig Dis. 2017; 9(2): 69–80.
9. WehKamp J, Gotz M, Herrlinger K, Steurer W, Stange E. Inflammatory Bowel Disease. Dtsch Arztebl Int. 2016 Feb; 113(5): 72–82.
10. Zhang Y, Li Y. Inflammatory Bowel Disease: Pathogenesis. World J Gastroenterol. 2014 Jan 7; 20(1): 91–99.
11. Mentella MC, Scaldaferri F, Pizzoferrato M, Gasbarrini A, Miggiano GAD. Nutrition, IBD and Gut Microbiota: A Review. Nutrients. 2020;12(944):1-20. DOI: 10.3390/nu12040944.
12. Liu TC, Stappenbeck TS. Genetics and Pathogenesis of Inflammatory Bowel Disease. Annu Rev Pathol. 2016 May 23;11:127-48. doi: 10.1146/annurev-pathol-012615-044152. Epub 2016 Feb 22. PMID: 26907531; PMCID: PMC4961083.
14. Lee SH, Kwon JE, Cho ML. Immunological pathogenesis of inflammatory bowel disease. Intest Res. 2018 Jan;16(1):26-42. doi: 10.5217/ir.2018.16.1.26. Epub 2018 Jan 18. PMID: 29422795; PMCID: PMC5797268.
15. Aniwan S, Santiago P, Loftus Jr E, Sang Hyoung P. The Epidemiology of Inflammatory Bowel Disease in Asia and Asian Immigrants to Western Countries. United European Gastroenterology Journal. 2022;10:1063-76. DOI: 10.1002/eug2.12350.
16. Santos MPC, Gomes C, Torres J. Familial and ethnic risk in inflammatory bowel disease. Ann Gastroenterol. 2018 Jan-Feb;31(1):14-23. doi: 10.20524/aog.2017.0208. Epub 2017 Oct 26. PMID: 29333063; PMCID: PMC5759609.
17. Shaler CR, Parco AA, Elhenawy W, Dourka J, Jury J, Verdu EF, Coombes BK. Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts. Nat Commun. 2021 Nov 18;12(1):6664. doi: 10.1038/s41467-021-26992-4. PMID: 34795263; PMCID: PMC8602651.
18. Rowe WA. Inflammatory Bowel Disease. Medscape, 2020. https://emedicine.medscape.com/article/179037-overview
19. Long MD, Kappelman MD, Martin CF, et al. Role of Nonsteroidal Anti-Inflammatory Drugs in Exacerbations of Inflammatory Bowel Disease. J Clin Gastroenterol. 2016;50(2):152-6
24. Salgado VCL, Luiz RR, Boéchat NLF, Leão IS, Schorr BDC, Parente JML, Lima DC, Silveira Júnior ES, Silva GOS, Almeida NP, Vieira A, de Bueno MLQ, Chebli JM, Bertges ÉR, Brugnara LMDC, Junqueira Neto C, Campbell SBG, Discacciati LL, Cézar JPS, Nunes T, Kaplan GG, Zaltman C. Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil. World J Gastroenterol. 2020 Jul 7;26(25):3611-3624. doi: 10.3748/wjg.v26.i25.3611. PMID: 32742130; PMCID: PMC7366056.

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Etiologi Inflammatory Bowel Disease

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