Ketoprofen

Oleh :

dr. DrRiawati MMedPH

Ketoprofen adalah suatu asam aril alkanoat, derivat asam karboksilat, obat dari golongan antiinflamasi nonsteroid (NSAID). Obat ini digunakan sebagai terapi simtomatik untuk berbagai kondisi, di antaranya untuk osteoartritis, reumatoid artritis, dismenorea, dan manajemen nyeri akut. Sebagai NSAID, obat ini memiliki efek terapi antiinflamasi, analgesik, dan antipiretik.

Nama kimia: 2-(3-benzoylphenyl)-propionic acid. Ketoprofen berupa bubuk putih/kekuningan hingga keabu-abuan, halus hingga berbentuk granular. Secara bebas larut dalam etanol, kloroform, aseton, eter, benzene, alkali kuat, namun secara praktis, tidak larut dalam air pada suhu sekitar 20^o C.[1-6]

TABEL 1 Deskripsi Singkat Ketoprofen

Perihal	Deskripsi
Kelas	Analgesik[7,8]
Sub-kelas	Analgesik nonnarkotik dan antipiretik[7,8]
Akses	Resep dokter[9]
Wanita hamil	Kategori C oleh FDA dan TGA. Kategori D untuk wanita hamil trimester akhir[10-13]
Wanita menyusui	Keamanan tidak diketahui
Anak-anak	Efektivitas dan keamanan tidak diketahui
Infant	Efektivitas dan keamanan tidak diketahui
FDA	Black Box Warning: risiko serius kardiovaskular dan gastrointestinal[5,14]

Referensi

1. Upton, R.A., et al., Effects of probenecid on ketoprofen kinetics [Abstract]. Clin Pharmacol Ther, 1982. 31(6): p. 705-12

2. Carbone, C., et al., The safety of ketoprofen in different ages. Journal of Pharmacology & Pharmacotherapeutics, 2013. 4(Suppl1): p. S99-S103

3. US National Library of Medicine: PubChem Database. Ketoprofen. May 2017; Available from: https://pubchem.ncbi.nlm.nih.gov/compound/ketoprofen#section=Top

4. Rigourd, V., et al., Is Ketoprofen Safe to Use When Breastfeeding? J Pharmacol Clin Res, 2015. 1(1): p. 001-006

5. FDA. Ketoprofen extended release. 2007; Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/019816s011lbl.pdf

6. Drugs.com. Ketoprofen. May 2017; Available from: https://www.drugs.com/cdi/ketoprofen.html

7. Kementerian Kesehatan R.I. Daftar Obat Esensial Nasional 2013. 2014; Available from: http://binfar.kemkes.go.id/2014/02/daftar-obat-esensial-nasional-2013/#.WM-TUbVMRjo

8. WHO. Essential medicines. 2017; Available from: http://www.who.int/medicines/services/essmedicines_def/en/

9. BPOM: Badan Pengawas Obat dan Makanan. Ketoprofen. 2015; Available from: http://pionas.pom.go.id/monografi/ketoprofen

10. FDA. Pregnancy and Lactation Labeling (Drugs) Final Rule. 12 March 2014; Available from: https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Labeling/ucm093307.htm

11. FDA. FDA Approved Drug Products. 2017; Available from: http://www.accessdata.fda.gov/scripts/cder/daf/

12. TGA: Therapeutic Goods Administration Department of Health Australian Government. The Australian categorisation system for prescribing medicines in pregnancy. December 2016; Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

13. TGA: Therapeutic Goods Administration Department of Health Australian Government. Definitions of the Australian categories for prescribing medicines in pregnancy. May 2011; Available from: https://www.tga.gov.au/australian-categorisation-system-prescribing-medicines-pregnancy

14. Drugs.com. Ketoprofen Pregnancy and Breastfeeding Warnings. May 2017; Available from: https://www.drugs.com/pregnancy/ketoprofen.html

15. Celebi, S., et al., Antipyretic effect of ketoprofen. Indian J Pediatr, 2009. 76(3): p. 287-91

16. FAO of the United Nations. The analgesic effect of ketoprofen for use in treating equine colic as compared to flunixin meglumine [Paper in 1991]. 2017; Available from: http://agris.fao.org/agris-search/search.do?recordID=US9179013

17. Drugs.com. Ketoprofen Dosage. May 2017; Available from: https://www.drugs.com/dosage/ketoprofen.html

18. Akural, E.I., et al., Effects of combination treatment with ketoprofen 100 mg + acetaminophen 1000 mg on postoperative dental pain: a single-dose, 10-hour, randomized, double-blind, active- and placebo-controlled clinical trial [Abstract]. Clin Ther, 2009. 31(3): p. 560-8

19. Osipova, N.A., et al., Ketoprofen (ketonal): a drug for preventing and treating postoperative pain [Abstract]. Anesteziol Reanimatol, 1999(6): p. 71-4

20. Drugs.com. Ketoprofen Drug Interactions. May 2017; Available from: https://www.drugs.com/drug-interactions/ketoprofen.html

21. Drugs.com. Ketoprofen Side Effects. May 2017; Available from: https://www.drugs.com/sfx/ketoprofen-side-effects.html

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