Penatalaksanaan Schizophrenia

Oleh :

dr. Jennifer

Penatalaksanaan schizophrenia atau skizofrenia bertujuan untuk meredakan dan mengontrol gejala, karena belum ada obat yang dapat menyembuhkan penyakit ini. Untuk itu, penatalaksanaan harus dilakukan seumur hidup, mencakup pemberian medikamentosa dan terapi psikososial. Dalam beberapa kasus, pasien mungkin memerlukan rawat inap, bila berpotensi membahayakan diri sendiri atau orang lain.[5]

Tata Laksana Farmakologi

Obat-obat yang dapat digunakan untuk pasien schizophrenia adalah berasal dari golongan antipsikotik. Golongan obat ini dianggap dapat mengendalikan gejala dengan mempengaruhi neurotransmiter dopamin di otak. Tujuan pengobatan dengan antipsikotik adalah untuk mengontrol tanda dan gejala schizophrenia secara efektif, dengan dosis serendah mungkin.[5]

Referensi

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23. Solmi M, Murru A, Pacchiarotti I, et al. Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review. Ther Clin Risk Manag. 2017 Jun 29;13:757-777. doi: 10.2147/TCRM.S117321. PMID: 28721057; PMCID: PMC5499790.
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25. Zhornitsky S, Stip E. Oral versus Long-Acting Injectable Antipsychotics in the Treatment of Schizophrenia and Special Populations at Risk for Treatment Nonadherence: A Systematic Review. Schizophr Res Treatment. 2012;2012:407171. doi: 10.1155/2012/407171. Epub 2012 Feb 15. PMID: 22966436; PMCID: PMC3420751.
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27. Schreiner A, Aadamsoo K, Altamura AC, et al. Paliperidone palmitate versus oral antipsychotics in recently diagnosed schizophrenia. Schizophr Res. 2015 Dec;169(1-3):393-399. doi: 10.1016/j.schres.2015.08.015. Epub 2015 Oct 1. PMID: 26431793.
28. Park SC, Choi MY, Choi J, et al. Comparative Efficacy and Safety of Long-acting Injectable and Oral Second-generation Antipsychotics for the Treatment of Schizophrenia: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2018 Nov 30;16(4):361-375. doi: 10.9758/cpn.2018.16.4.361. PMID: 30466208; PMCID: PMC6245299.
29. Andreou C, Moritz S. Editorial: Non-pharmacological Interventions for Schizophrenia: How Much Can Be Achieved and How?. Front Psychol. 2016;7:1289. Published 2016 Aug 29. doi:10.3389/fpsyg.2016.01289

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