Pendahuluan Atorvastatin

Oleh :

dr. DrRiawati MMedPH

Atorvastatin adalah obat golongan statin yang berperan sebagai inhibitor sintetik terhadap enzim reduktase HMG CoA. Obat ini bermanfaat untuk menurunkan kadar lipid pada hiperkolesterolemia atau dislipidemia.

Nama kimia atorvastatin (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid. Formula molekular atorvastatin adalah C33H35FN2O5. Atorvastatin secara luas dikenal di masyarakat dengan nama dagang Lipitor®.

Atorvastatin bekerja menurunkan kadar kolesterol LDL dan trigliserida, serta meningkatkan kadar HDL. Efek terapi atorvastatin ini, memiliki asosiasi yang erat untuk menurunkan risiko stroke, serangan jantung, atau komplikasi penyakit jantung lainnya yang juga menderita diabetes mellitus tipe 2, dan penyakit jantung koroner.[1-6]

TABEL 1. Deskripsi Singkat Atorvastatin

Perihal	Deskripsi
Kelas	Obat Kardiovaskuler[7]
Subkelas	Antihiperlipidemia[7]
Akses	Resep[8]
Wanita hamil	Kategori FDA: X[9,10], Kategori TGA: D[11,12]
Wanita menyusui	Ekskresi ke ASI belum diketahui secara pasti
Anak-anak	Bilamana perlu sesuai usia dan aturan
Infant	Tidak direkomendasikan
FDA	Approved[13]

Referensi

1. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 2002. 106(25): p. 3143-421.
2. Drugs.com. Atorvastatin. November 2017; Available from: https://www.drugs.com/atorvastatin.html.
3. Endo, A., A historical perspective on the discovery of statins. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2010. 86(5): p. 484-493.
4. Hoefle, M.L., The Early History of Parke-Davis and Company. Bull. Hist. Chem, 2000. 25(1): p. 28-34.
5. Roth, B.D., The discovery and development of atorvastatin, a potent novel hypolipidemic agent [Abstract]. Prog Med Chem, 2002. 40: p. 1-22.
6. Zhao, H. and Z. Guo, Medicinal chemistry strategies in follow-on drug discovery. Drug discovery today, 2009. 14(9-10): p. 516-522.
7. BPOM: Badan Pengawas Obat dan Makanan. Atorvastatin. 2015 21 November 2017]; Available from: http://pionas.pom.go.id/monografi/atorvastatin.
8. BPOM: Badan Pengawas Obat dan Makanan. Lipitor. 2015 21 November 2017]; Available from: http://pionas.pom.go.id/obat/lipitor.
9. FDA. Pregnancy and Lactation Labeling (Drugs) Final Rule. 12 March 2014; Available from: https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Labeling/ucm093307.htm.
10. FDA. Liptruzet. 2013-2017 21 November 2017]; Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/200153s006lbl.pdf.
11. TGA: Therapeutic Goods Administration Department of Health Australian Government. The Australian categorisation system for prescribing medicines in pregnancy. December 2016; Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname.
12. TGA: Therapeutic Goods Administration Department of Health Australian Government. Definitions of the Australian categories for prescribing medicines in pregnancy. May 2011; Available from: https://www.tga.gov.au/australian-categorisation-system-prescribing-medicines-pregnancy.
13. FDA. FDA Approved Drug Products: Atorvastatin. 2017; Available from: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=browseByLetter.page&productLetter=A&ai=0.

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Pendahuluan Atorvastatin

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