Pendahuluan Atorvastatin

Oleh :

dr. DrRiawati MMedPH

Atorvastatin adalah obat golongan statin yang berperan sebagai inhibitor sintetik terhadap enzim reduktase β-Hydroxy β-methylglutaryl-CoA (HMG–CoA). Obat ini bermanfaat untuk menurunkan kadar lipid pada hiperkolesterolemia atau dislipidemia.

Nama kimia atorvastatin (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid. Formula molekular atorvastatin adalah C33H35FN2O5.[2,4]

Atorvastatin bekerja menurunkan kadar kolesterol low-density lipoprotein (LDL) dan trigliserida, serta meningkatkan kadar high-density lipoprotein (HDL). Efek terapi atorvastatin ini, berhubungan erat dengan penurunan risiko stroke, serangan jantung, atau komplikasi penyakit jantung dan kardiovaskular lainnya yang juga menderita diabetes mellitus tipe 2, dan penyakit jantung koroner.[1–6]

Referensi

1. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 2002. 106(25): p. 3143-421.
2. Drugs.com. Atorvastatin. November 2017; Available from: https://www.drugs.com/atorvastatin.html. → McIver LA, Siddique MS. Atorvastatin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK430779/
3. Endo, A., A historical perspective on the discovery of statins. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2010. 86(5): p. 484-493.
4. Hoefle, M.L., The Early History of Parke-Davis and Company. Bull. Hist. Chem, 2000. 25(1): p. 28-34. → PubChem. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 60823, Atorvastatin. https://pubchem.ncbi.nlm.nih.gov/compound/Atorvastatin
5. Roth, B.D., The discovery and development of atorvastatin, a potent novel hypolipidemic agent. Prog Med Chem, 2002. 40: p. 1-22.
6. Zhao, H. and Z. Guo, Medicinal chemistry strategies in follow-on drug discovery. Drug discovery today, 2009. 14(9-10): p. 516-522.
7. BPOM: Badan Pengawas Obat dan Makanan. Atorvastatin. 2015, 21 November 2017; http://pionas.pom.go.id/monografi/atorvastatin
8. BPOM: Badan Pengawas Obat dan Makanan. Lipitor. 2015, 21 November 2017]; http://pionas.pom.go.id/obat/lipitor
11. TGA: Therapeutic Goods Administration Department of Health Australian Government. The Australian categorisation system for prescribing medicines in pregnancy. December 2016; https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname
12. TGA: Therapeutic Goods Administration Department of Health Australian Government. Definitions of the Australian categories for prescribing medicines in pregnancy. May 2011; https://www.tga.gov.au/australian-categorisation-system-prescribing-medicines-pregnancy
13. FDA. FDA Approved Drug Products: Atorvastatin. 2017; https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=browseByLetter.page&productLetter=A&ai=0.
21. Drugs and Lactation Database. Bethesda (MD): National Library of Medicine (US); 2006-. Atorvastatin. Updated 2021 Sep 20. https://www.ncbi.nlm.nih.gov/books/NBK501361/
22. U.S. Food and Drug Administration (FDA). LIPITOR® (atorvastatin calcium), FDA-HIGHLIGHTS OF PRESCRIBING INFORMATION . U.S. Food and Drug Administration (FDA), 2009. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020702s056lbl.pdf

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