Propranolol VS Captopril untuk Penatalaksanaan Hemangioma Infantil

Oleh :

dr. Afiffa Mardhotillah

Propranolol adalah obat yang masih menjadi pilihan dalam tata laksana hemangioma infantil. Namun, efek samping yang ditimbulkannya menyebabkan banyak peneliti berusaha mencari alternatif tata laksana yang lain, salah satunya captopril.

Hemangioma infantil adalah suatu tumor mikrovaskular, dengan karakteristik proliferasi berawal saat bayi dan dapat mengalami involusi spontan. Di dunia, terdapat sekitar 4-10% bayi dengan hemangioma infantil.

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Referensi

1. Itinteang T, Withers AH, Davis PF, Tan ST. Biology of infantile hemangioma. Front Surg. 2014. 1:38 URL: https://doi.org/10.3389/fsurg.2014.00038
2. Antaya RJ, Wells MJ, James WD, Ortonne JP. Infantile hemangioma. 2018. URL: https://emedicine.medscape.com/article/1083849-overview
3. Drolet BA, Frommelt PC, Chamlin SL, Haggstorm A, Bauman NM, Chiu YE, et al. Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics. 2013 Jan;131(1):128-40. URL: https://www.ncbi.nlm.nih.gov/pubmed/23266923
4. Tan ST, Itinteang T, Day DJ, O’Donnell C, Mathy JA, Leadbitter P. Treatment of infantile haemangioma with captopril. Br J Dermatol. 2012;167(3):619-24 URL: https://www.ncbi.nlm.nih.gov/pubmed/22533490
5. Zaheer H, Rasheed H, El-komy MM, Hegazy RA, Gawdat HI, Halim DM, et al. Propranolol versus captopril in the treatment of infantile hemangioma (IH): A randomized controlled trial. J Am Acad Dermatol. 2016;74(3)499-505 URL: https://www.jaad.org/article/S0190-9622(15)02283-5/pdf
6. Tan CE. Itinteang T, Leadbitter P, Marsh R, Tan ST. Low‐dose propranolol regimen for infantile haemangioma J Paediatr Child Health. 2014. URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jpc.12720
7. Pineda IF, Williams R, Laureano LO, Jones R. Cardiovascular drugs in the treatment of infantile hemangioma. World J Cardiol. 2016; 8(1):74-80 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728108/
8. Carine F, Quintal MC, Giguere C, Khalfallah SA, Guibaud L, Powell J, et al. Propranolol as First-line Treatment of Head and Neck Hemangiomas. Arch Otolaryngol Head Neck Surg. 2011;137(5):471-8 URL: https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/716282?resultClick=1
9. Prey S, Voisard JJ, Delarue A, Lebbe G, Taieb A, Labreze CL, et al. Safety of Propranolol Therapy for Severe Infantile Hemangioma. 2016; 315(4). URL: https://jamanetwork.com/journals/jama/fullarticle/2484326?resultClick=1
10. Sulzberger L, Baillie R, Itinteang T, de Jong S, Marsh R, Leadbitter P, et al. Serum levels of renin, angiotensin-converting enzyme and angiotensin II in patients treated by surgical excision, propranolol and captopril for problematic proliferating infantile haemangioma. J Plast Reconstr Aesthet Surg. 2016; 69(3):381-6. URL: https://www.ncbi.nlm.nih.gov/pubmed/26612192

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