Antibodi Monoklonal terhadap CGRP sebagai Terapi Preventif Migraine

Oleh :

dr. Andriani Putri Bestari, Sp.S

Antibodi monoklonal terhadap calcitonin gene-related peptide (CGRP) diduga bermanfaat dalam pencegahan migraine. Migraine merupakan penyakit serebral yang cukup sering ditemui, memiliki gejala mengganggu (termasuk nyeri kepala), dan berdampak pada kualitas hidup pasien. Penelitian dalam dekade terakhir menekankan pentingnya peran CGRP dalam patofisiologi migraine. Pengembangan antibodi terhadap CGRP atau reseptornya sebagai terapi preventif migraine yang spesifik juga terus dilakukan. [1]

Peran CGRP dalam Patofisiologi Migraine

Patofisiologi migraine merupakan proses yang kompleks dan multifaktorial. Salah satu proses patofisiologi yang dikenal adalah proses cortical spreading depression (CSD). CSD adalah gelombang depolarisasi neuron yang menyebar secara perlahan (2-6 mm/menit) yang diikuti oleh supresi neuron yang bertahan lebih lama. CSD merupakan proses yang diduga menyebabkan aura pada migraine.

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Referensi

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