Pengaruh Riwayat Infeksi Dengue Terhadap Patogenisitas

Oleh :

dr.Eduward Thendiono, SpPD,FINASIM

Riwayat infeksi dengue sebelumnya diduga mempengaruhi patogenisitas infeksi baru, namun data ilmiah terkait hal ini masih minimal. Virus Dengue (DENV) termasuk dalam famili Flaviviridae, genus Flavivirus, dan ditransmisikan ke manusia lewat gigitan nyamuk Aedes. Infeksi DENV akan menyebabkan demam dengue atau demam berdarah dengue.

Interaksi Imun Serotipe Virus Dengue

Berdasarkan data neutralization assay, ada empat serotipe virus dengue yakni DENV-1, DENV-2, DENV-3, dan DENV-4. Keempat serotipe virus ini bersifat cross-reactive secara imunologis. Pasien dapat terinfeksi lebih dari salah satu serotipe virus dengue sepanjang hidupnya. [1-6]

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Referensi

1. Malavige GN, Fernando N, Ogg G. Pathogenesis of Dengue viral infections. Sri Lankan Journal of Infectious Diseases 2011; 1(1): 2-8 DOI: http://dx.doi.org/10.4038/sljid.v1i1.2987
2. Sellahewa KH. Pathogenesis of Dengue Haemorrhagic Fever and Its Impact on Case Management. ISRN Infectious Diseases 2013; 2013, article ID 571646, 6 pages. https://doi.org/10.5402/2013/571646.
3. Yacoub S, Mongkolsapaya J, Screaton G. Recent advances in understanding dengue [version 1; referees: 3 approved] F1000Research 2016, 5(F1000 Faculty Rev):78 doi:10.12688/f1000research.6233.1
4. Khetarpal N, Khanna I. Dengue Fever: Causes, Complications, and Vaccine Strategies. Journal of Immunology Research 2016, Article ID 6803098, 14 pages. https://doi.org/10.1155/2016/6803098.
5. Bhatt S et al. The global distribution and burden of dengue. Nature. 2013 ;496(7446):504-7. doi: 10.1038/nature12060
6. Gordon A et al. The Nicaraguan pediatric dengue cohort study: incidence of inapparent and symptomatic dengue virus infections, 2004-2010. PLoS Negl Trop Dis. 2013;7(9):e2462. doi: 10.1371/journal.pntd.0002462.
7. Sierra B et al. Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?. Cellular Immunology 2010;262 :134–140. https:// doi.org/10.1016 /j.cellimm. 2010.02.005
8. Rothman AL, Medin CL, Friberg H, Currier JR. Immunopathogenesis versus Protection in Dengue Virus Infections. Curr Trop Med Rep2014;1(1): 13-20. DOI 10.1007/s40475-013-0009-0
9. Soo K-M, Khalid B, Ching S-M, Chee H-Y. Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections. PLoS ONE 2016; 11(5): e0154760. doi:10.1371/journal.pone.0154760.
10. Martina BE, Koraka P, Osterhaus AD. Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev. 2009 Oct;22(4):564-81. doi: 10.1128/CMR.00035-09.
11. Friberg H et al. Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans. Scientific reports 2011.1(): 51. doi:10.1038/srep00051.
12. Thomas SJ, Rohtman AL. Dengue virus infection: pathogenesis. UpToDate [Online]. Availbale in URL: https://www. uptodate.com /contents/dengue-virus-infection-pathogenesis
13. Katzelnick LC et al. Antibody-dependent enhancement of severe dengue disease in humans. Science. 2017;358(6365):929-932. doi: 10.1126/science.aan6836.
14. Tsang TK et al. Effects of infection history on dengue virus infection and pathogenicity.Nat Commun. 2019;10(1):1246. doi: 10.1038/s41467-019-09193-y.

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