Koenzim Q10 adalah senyawa larut lemak yang diduga bermanfaat dalam tata laksana gagal jantung. Gagal jantung, baik tipe preserved atau reduced ejection fraction, meningkatkan morbiditas dan mortalitas pasien di seluruh dunia. Gagal jantung merupakan kondisi energy-depleted yang berkaitan dengan rendahnya produksi adenosin trifosfat (ATP), disfungsi mitokondria, abnormal calcium handling, peningkatan reactive oxygen species, dan disfungsi endotel miokardium.
Saat ini sudah tersedia banyak terapi gagal jantung yang bekerja dengan memodulasi jalur neurohormonal, seperti pada aksis renin-angiotensin-aldosteron. Namun, terapi tersebut mempunyai keterbatasan akibat efek sampingnya, sehingga masih dibutuhkan opsi terapi lain dengan profil netral terhadap hemodinamik pasien. [1-4]
Mekanisme Kerja Koenzim Q10 pada Gagal Jantung
(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)
Referensi
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