Bahaya Kandungan Triclosan dan Triclocarban pada Sabun Antiseptik

Oleh :

Immanuela Hartono

Triclosan dan triclocarban merupakan dua antiseptik yang mendapat peringatan akan potensi bahayanya. Pada tahun 2017, Food and Drugs Administration (FDA) mengeluarkan peraturan mengenai bahaya dari sabun antiseptik terhadap kesehatan tubuh, juga kesehatan lingkungan. Dua zat aktif yang mendapat sorotan karena potensi bahayanya adalah triclosan dan triclocarban.

Triclosan dan triclocarban tidak ditemukan bermanfaat sebagai antiseptik yang efektif. Selain itu, penggunaannya sebagai produk rumah tangga diasosiasikan dengan peningkatan risiko atopik atau alergi pada anak. Dokter sebaiknya mengedukasi masyarakat untuk menghindari produk rumah tangga yang mengandung kedua zat tersebut.

Pernyataan FDA mengenai Kandungan Zat Aktif pada Sabun Antiseptik

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

1. Food and Drug Administration. Safety and effectiveness of consumer antiseptic; topical antimicrobial drug products for over-the-counter human use. Federal Register. 2016. https://www.federalregister.gov/documents/2016/09/06/2016-21337/safety-and-effectiveness-of-consumer-antiseptics-topical-antimicrobial-drug-products-for
2. Bergstrom KG. Update on antibacterial soaps: the FDA takes a second look at triclosans. US National Library of Medicine. 2014 Apr; 13(4): 501-3. https://www.ncbi.nlm.nih.gov/pubmed/24719072
3. Halden RU, Lindeman AE, Aiello A, Andrews D, Arnold WA, Fair P, etc. The Florence Statement on Triclosan and Triclocarban. Environmental Health Perspectives. 2017 Jun; 125(6). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644973/
4. Bakare BF, Adeyinka GC. Occurrence and Fate of Triclosan and Triclocarban in Selected Wastewater Systems across Durban Metropolis, KwaZulu-Natal, South Africa. Int J Environ Res Public Health. 2022 Jun 1;19(11):6769. doi: 10.3390/ijerph19116769.
5. Westfall C, Flores-Mireles AL, Robinson JI, Lynch AJL, Hultgren S, Henderson JP, Levin PA. The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance In Vitro and Reduces Antibiotic Efficacy up to 100-Fold In Vivo. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02312-18. doi: 10.1128/AAC.02312-18.
6. Rehman SU, Shaqfat F, Usman M, et al. Triclosan Induced Oxidative Stress, Estrogenicity, Mutagenicity, Carcinogenicity, and Genotoxicity: A Novel Therapeutic Approach. Biomed Press. 2021;8(12):4750-4774
7. Waidyanatha S, Black SR, Patel PR, Watson SL, Snyder RW, Sutherland V, Stanko J, Fennell TR. Disposition and metabolism of antibacterial agent, triclocarban, in rodents; a species and route comparison. Xenobiotica. 2020 Dec;50(12):1469-1482. doi: 10.1080/00498254.2020.
8. Li A, Zhuang T, Zhu Q, Song M, Liao C, Jiang G. Concentration and distribution of parabens, triclosan, and triclocarban in pregnant woman serum in China. Sci Total Environ. 2020 Mar 25;710:136390. doi: 10.1016/j.scitotenv.2019.136390.
9. Halden RU. On the need and speed of regulating triclosan and triclocarban in the united states. US National Library of Medicine. 2014 Apr; 48(7): 3603-3611. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974611/
10. Hong S, Kwon HJ, Choi WJ, Lim WR, Kim J, Kim K. Association between exposure to antimicrobial household products and allergic symptoms. Environmental Health and Toxicology. 2014 Nov; 29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243727/
11. Xie X, Lu C, Wu M, et al. Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013-2014). Environ Int. 2020 Mar;136:105445. doi: 10.1016/j.envint.2019.105445.
12. Ribado JV, Ley C, Haggerty TD, Tkachenko E, Bhatt AS, Parsonnet J. Household triclosan and triclocarban effects on the infant and maternal microbiome. EMBO Mol Med. 2017 Dec;9(12):1732-1741. doi: 10.15252/emmm.201707882.